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N209: Reproductive Health Study Guide learning complications o Tend to seek prenatal care later in pregnancy • Gestational diabetes o Affects 9.2% of all pregnancies according to the CDC o Cause is unknown; may be hormone related o Testing is done at first prenatal visit with one hour GTT if preexisting risk factors are present (history of GDM with previous pregnancy, BMI over 30, first degree relative, glycosuria); average risk done at 24-28 weeks gestation; 1 hour GTT: 50 gm load with BS <130 (if 130 or greater, will do three hr GTT) o Treatment depends upon severity of condition, usually is diet and exercise with blood glucose monitoring Preprandial: 95 mg/dl or less 1 hour postprandial: 140 mg/dl or less 2 hour postprandial: 120 mg/dl or less o Multiple fetal andmaternal risks related tomacrosomia and circulatory changes (RDS, fetal death, jaundice, and hypoglycemia after birth) • Gestational trophoblastic disease (GTD) o Group of rare tumors than involve abnormal growth of cells outside of the uterus (begin in the cells that would normally become the placenta) o Most are benign but some can be malignant o All forms can be treated o Hydatiform mole: Molar pregnancy In rare cases a normal fetus can develop, but in most cases, it is impossible for a fetus to form Can be complete or partial o Invasive mole: Hydatiform mole that grows into the uterine muscle o Choriocarcinoma: Malignant form of GTD Half start as molar pregnancies One quarter develop in those who have had a spontaneous abortion, elective abortion, or ectopic pregnancy Can develop after normal pregnancy and delivery o Placental-site trophoblastic tumor: A rare form of GTD that develops where the placenta attaches to the uterus Develops after normal pregnancy or abortion, or after removal of hydatiform mole Treated with surgery (most other GTDs respond to chemo drugs) o Epitheliod trophoblastic tumor: Rare form, hard to diagnose Can often be confused with cervical cancer Main treatment is surgery
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