Pathophysiology

Pathophysiology Study Guide

Table of Contents Chapter 1: Cell Biology, Mechanisms of Cell Injury, and Neoplasia...................................................10 1.1 Cellular Adaptation.................................................................................................................................................. 10 Atrophy............................................................................................................................................................................................... 10 Hypertrophy ..................................................................................................................................................................................... 10 Hyperplasia....................................................................................................................................................................................... 11 Metaplasia ......................................................................................................................................................................................... 11 Dysplasia............................................................................................................................................................................................ 11 1.2 Cellular Injury............................................................................................................................................................ 11 Reversible Cell Injury ................................................................................................................................................................... 12 Irreversible Cell Injury................................................................................................................................................................. 12 Mechanisms of Cell Injury........................................................................................................................................................... 13 Intracellular Accumulation......................................................................................................................................................... 13 1.3 Genetic Disorders ..................................................................................................................................................... 14 Chromosomal Abnormalities..................................................................................................................................................... 14 Mutations........................................................................................................................................................................................... 15 1.4 Neoplasia ..................................................................................................................................................................... 15 Nomenclature/Classification/Naming of Neoplasias...................................................................................................... 15 Mechanism of Oncogenesis ........................................................................................................................................................ 17 Tumor Markers ............................................................................................................................................................................... 18 Effects of Tumors on the Host................................................................................................................................................... 19 Chapter One Practice Exam.......................................................................................................................................... 20 Chapter 2: Host Defense/Hematology .........................................................................................................21 2.1 Alterations in Integument Function .................................................................................................................. 21 Mechanical Barriers ...................................................................................................................................................................... 21 Burns ................................................................................................................................................................................................... 22 Skin Disorders.................................................................................................................................................................................. 24 Allergic Response ........................................................................................................................................................................... 25 Neoplastic .......................................................................................................................................................................................... 25 2.2 Inflammation.............................................................................................................................................................. 26 Local Manifestation ....................................................................................................................................................................... 26 Systemic Manifestation:............................................................................................................................................................... 27 2.3 Alterations in Wound Healing.............................................................................................................................. 28 Dysfunction in Inflammatory Response................................................................................................................................ 28 Nutritional Factors......................................................................................................................................................................... 29 Congenital Factors ......................................................................................................................................................................... 29 Complicating Factors .................................................................................................................................................................... 29 Impaired Infusion........................................................................................................................................................................... 30 2.4 Alterations in Immune Function......................................................................................................................... 30 Primary Immune Deficiencies................................................................................................................................................... 30 Secondary Immune Deficiencies .............................................................................................................................................. 31

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